EPIDEMICS
"In case you ever wondered why a large number of your ancestors  disappeared during a certain period in history, this might help.  Epidemics have always had a great influence on people - and thus  influencing, as well, the genealogists trying to trace them.  Many  cases of people disappearing from records can be traced to dying  during an epidemic or moving away from the affected area.  Some of the major epidemics in the United States are listed below:"
YEAR
LOCATION
EPIDEMIC
1657 Boston  Measles 
1687 Boston Measles 
1690 New York Yellow Fever
1713 Boston Measles
1729 Boston Measles
1732-3 Worldwide Influenza
1738 South Carolina Smallpox
1739-40 Boston Measles
1747 CT,NY,PA,SC  Measles
1759 North America [areas inhabited by white people] Measles
1761 N. Amer and West Indies Influenza
1772 North America Measles
1775 North America [especially hard in NE]  Unknown
epidemic 
1775-6 Worldwide [one of the worst epidemics]  Influenza
1783 Dover, DE ["extremely fatal"] Bilious Disorder
1788 Philadelphia and New York Measles
1793 Vermont [a "putrid" fever]
and Influenza 
1793 VA [killed 500 in 5 counties in 4 weeks] Influenza
1793 Philadelphia [one of the worst epidemics] Yellow Fever 
1793 Harrisburg, PA [many unexplained deaths] Unknown
1793 Middletown, PA [many mysterious deaths] Unknown
1794 Philadelphia, PA  Yellow Fever
1796-7 Philadelphia, PA Yellow Fever
1798 Philadelphia, PA [one of the worst]  Yellow Fever 
1803 New York Yellow Fever
1820-3 Nationwide [starts-Schuylkill River and 
 spreads]
"Fever"
1831-2 Nationwide [brought by English emigrants] Asiatic Cholera 
1832 NY City and other major cities Cholera
1833 Columbus, OH Cholera
1834 New York City  Cholera
1837 Philadelphia Typhus
1841 Nationwide [especially severe in the south] Yellow Fever 
1847 New Orleans Yellow Fever
1847-8 Worldwide Influenza
1848-9 North America Cholera
1849 New York Cholera
1850 Nationwide Yellow Fever
1850-1 North America Influenza
1851 Coles Co., IL, The Great Plains, and Missouri  Cholera
1852 Nationwide [New Orleans-8,000 die in summer] Yellow Fever
1855 Nationwide [many parts] Yellow Fever
1857-9 Worldwide [one of the greated epidemics] Influenza
1860-1 Pennsylvania Smallpox
1865-73 Philadelphia, NY, Boston, New Orleans Smallpox
Baltimore, Memphis, Washington DC Cholera
-  [A series of recurring epidemics of: Typhus
Typhoid
Scarlet Fever
Yellow Fever
1873-5 North America and Europe Influenza
1878 New Orleans [last great epidemic] Yellow Fever
1885 Plymouth, PA Typhoid
1886 Jacksonville, FL Yellow Fever
1918 Worldwide[high point yr] more people were hospitalized in WWI from this epidemic than wounds.  US Army training camps became death camps, with 80% death rate in some camps  Influenza 
--ROOTS-L Digest,  Volume 98 : Issue 328 Today's Topics: [RICH WIGHT richmwight@home.com

 
Here's the definition and time frame for Cholera
"An acute, infectious disease characterized by profuse diarrhea, vomiting,  and cramps. Cholera is spread by feces-contaminated water and food. Major epidemics struck the United States in the years 1832, 1849, and 1866. 
 
Here are a few URL's for time frames and definitions
  http://www.rootsweb.com/~ote/disease.htm 
http://www.vineyard.net/vineyard/history/index3.htm
http://www.uftree.com/UFT/HowTos/SettingOut/disease1.html 
source: rootsweb.com